| Primary Identifier | MGI:2182338 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Cyp24a1 |
| Transmission | Germline | Strain of Origin | 129S4/SvJae |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exons 9 and 10, the latter encoding the heme-binding domain, were replaced with a PGK-neo selection cassette. Transcript was reported to be undetectable in homozygous mutant mice. Neither an immunoassay nor HPLC fractionation followed by a competitive binding assay could detect the enzymatic product, 24,25-dihydroxyvitamin D, of the encoded protein in homozygous mutant mice. |
