| First Author | Carr DJ | Year | 2005 |
| Journal | J Virol | Volume | 79 |
| Issue | 14 | Pages | 9341-5 |
| PubMed ID | 15994831 | Mgi Jnum | J:100121 |
| Mgi Id | MGI:3586970 | Doi | 10.1128/JVI.79.14.9341-9345.2005 |
| Citation | Carr DJ, et al. (2005) RNA-dependent protein kinase is required for alpha-1 interferon transgene-induced resistance to genital herpes simplex virus type 2. J Virol 79(14):9341-5 |
| abstractText | We investigated the mechanism of resistance to genital herpes simplex virus type 2 (HSV-2) infection in mice transfected with the murine alpha-1 interferon (IFN-alpha1) transgene. In situ transfection of mice with the IFN-alpha1 transgene resulted in an elevation in an IFN-responsive gene, RNA-dependent protein kinase (PKR), but not 2',5'-oligoadenylate synthetases (OAS), in vaginal tissue. Coupled with the finding that mice lacking a functional PKR pathway were no longer resistant to genital HSV-2 infection following transfection with the IFN-alpha1 transgene in comparison to wild-type mice or mice lacking a functional OAS pathway, these results suggest that PKR is the dominant antiviral pathway activated by the IFN-alpha1 transgene. |
