| First Author | Lee H | Year | 2005 |
| Journal | Mol Carcinog | Volume | 44 |
| Issue | 3 | Pages | 219-22 |
| PubMed ID | 16167349 | Mgi Jnum | J:103869 |
| Mgi Id | MGI:3610816 | Doi | 10.1002/mc.20136 |
| Citation | Lee H, et al. (2005) NFATc3 deficiency may contribute to the development of mammary gland adenocarcinoma in aging female mice. Mol Carcinog 44(3):219-22 |
| abstractText | The nuclear transcription factor of activated T cells (NFAT) suggested to be a tumor suppressor. Here we report that two out of three NFATc3-/- and two in four NFATc3 +/- female mice developed aggressive mammary adenocarcinoma by 12.5 and 16 mo of age, respectively, with no occurrences in age-matched wild-type littermates (N-14). Thus, our data suggest that NFATc3 can suppress the development of mammary gland tumors in female mice. |
