| First Author | Kidd BL | Year | 2003 |
| Journal | Neuroreport | Volume | 14 |
| Issue | 17 | Pages | 2189-92 |
| PubMed ID | 14625445 | Mgi Jnum | J:103700 |
| Mgi Id | MGI:3610631 | Doi | 10.1097/00001756-200312020-00011 |
| Citation | Kidd BL, et al. (2003) Inhibition of inflammation and hyperalgesia in NK-1 receptor knock-out mice. Neuroreport 14(17):2189-92 |
| abstractText | We sought to characterise the contribution of the neuropeptide substance P to the outcome of two models of footpad inflammation of differing severity. In an intense inflammatory model produced by intra-plantar Mycobacterium tuberculosus (10 mg/ml) substantial reductions in footpad swelling, histological outcome and mechanical hyperalgesia were observed from early time points in mice lacking the neurokin-1 receptor for substance P compared with wild-type controls. Conversely, in a less intense model (M. tuberculosus 1 mg/ml) no differences were observed other than for a reduction in mechanical hyperalgesia at later time points (day 9 onwards). The results point to a previously unrecognised influence of substance P on peripheral tissue injury and the maintenance of hyperalgesia during more severe or more chronic phases of inflammatory disease. |
