| First Author | Llagostera E | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 12 | Pages | 2121-5 |
| PubMed ID | 19482024 | Mgi Jnum | J:150076 |
| Mgi Id | MGI:3849650 | Doi | 10.1016/j.febslet.2009.05.043 |
| Citation | Llagostera E, et al. (2009) High-fat diet induced adiposity and insulin resistance in mice lacking the myotonic dystrophy protein kinase. FEBS Lett 583(12):2121-5 |
| abstractText | Myotonic dystrophy 1 (MD1) is caused by a CTG expansion in the 3'-unstranslated region of the myotonic dystrophy protein kinase (DMPK) gene. MD1 patients frequently present insulin resistance and increased visceral adiposity. We examined whether DMPK deficiency is a genetic risk factor for high-fat diet-induced adiposity and insulin resistance using the DMPK knockout mouse model. We found that high-fat fed DMPK knockout mice had significantly increased body weights, hypertrophic adipocytes and whole-body insulin resistance compared with wild-type mice. This nutrient-genome interaction should be considered by physicians given the cardiometabolic risks and sedentary lifestyle associated with MD1 patients. |
