| First Author | Hegyi K | Year | 2004 |
| Journal | Immunol Lett | Volume | 92 |
| Issue | 1-2 | Pages | 193-7 |
| PubMed ID | 15081545 | Mgi Jnum | J:110970 |
| Mgi Id | MGI:3652463 | Doi | 10.1016/j.imlet.2003.11.029 |
| Citation | Hegyi K, et al. (2004) High leptin level is accompanied with decreased long leptin receptor transcript in histamine deficient transgenic mice. Immunol Lett 92(1-2):193-7 |
| abstractText | Leptin is a multifunctional cytokine and hormone that primarily acts in the hypothalamus and plays a key role in regulation of food intake and energy expenditure. Leptin acts through its receptor (OBR), the product of db gene that activates the Jak/STAT pathway predominantly. To exert its functions, leptin interacts with histamine as well. Histamine is a downstream effector of leptin as its release, metabolism is enhanced by leptin and hypothalamic histamine reduces food intake. In a bi-directional regulatory loop histamine also influences leptin concentration by inhibiting its expression. In this study we demonstrate that histamine deficiency elevates serum leptin level and decreases full-length leptin receptor isoform with a slight increase of the short one and results in mild late onset obesity. These observation can help to elucidate further the bi-lateral interaction of leptin and histamine, and therefore provide useful data to understand the pathomechanism of obesity. |
