| First Author | Wang Y | Year | 2008 |
| Journal | Cancer Res | Volume | 68 |
| Issue | 11 | Pages | 4039-44 |
| PubMed ID | 18519661 | Mgi Jnum | J:136437 |
| Mgi Id | MGI:3796312 | Doi | 10.1158/0008-5472.CAN-07-6314 |
| Citation | Wang Y, et al. (2008) Laforin confers cancer resistance to energy deprivation-induced apoptosis. Cancer Res 68(11):4039-44 |
| abstractText | A long-standing but poorly understood observation in experimental cancer therapy is the heterogeneity in cancer susceptibility to energy deprivation. Here, we show that the hexose kinase inhibitor 2-deoxyglucose (2-dG) preferentially kills cancer cells with defective laforin expression and significantly increases the survival of mice with aggressive lymphoma due to a genetic defect of the laforin-encoding Epm2a gene. Normal cells from Epm2a(-/-) mice also had greatly increased susceptibility to 2-dG. Thus, laforin is a novel regulator for cellular response to energy deprivation and its defects in cancer cells may be targeted for cancer therapy. |
