| First Author | Thompson NA | Year | 2001 |
| Journal | J Biol Chem | Volume | 276 |
| Issue | 30 | Pages | 27745-8 |
| PubMed ID | 11390367 | Mgi Jnum | J:70600 |
| Mgi Id | MGI:2137827 | Doi | 10.1074/jbc.C100222200 |
| Citation | Thompson NA, et al. (2001) Islet-brain1/JNK-interacting protein-1 is required for early embryogenesis in mice. J Biol Chem 276(30):27745-8 |
| abstractText | Islet-brain1/JNK-interacting protein-1 (IB1/JIP-1) is a scaffold protein that organizes the JNK, MKK7, and MLK1 to allow signaling specificity. Targeted disruption of the gene MAPK8IP1 encoding IB1/JIP-1 in mice led to embryonic death prior to blastocyst implantation. In culture, no IB1/JIP-1(-/-) embryos were identified indicating that accelerated cell death occurred during the first cell cycles. IB1/JIP-1 expression was detected in unfertilized oocytes, in spermatozoa, and in different stages of embryo development. Thus, despite the maternal and paternal transmission of the IB1/JIP-1 protein, early transcription of the MAPK8IP1 gene is required for the survival of the fertilized oocytes. |
