First Author | Hurd EA | Year | 2004 |
Journal | Infect Immun | Volume | 72 |
Issue | 7 | Pages | 4279-81 |
PubMed ID | 15213174 | Mgi Jnum | J:90993 |
Mgi Id | MGI:3045646 | Doi | 10.1128/IAI.72.7.4279-4281.2004 |
Citation | Hurd EA, et al. (2004) Increased susceptibility of secretor factor gene Fut2-null mice to experimental vaginal candidiasis. Infect Immun 72(7):4279-81 |
abstractText | Fut2-LacZ-null mice, which are a model of the human ABO and Lewis nonsecretor group, display increased susceptibility to experimental yeast vaginitis, indicating a role for alpha(1,2)fucosylated cervical glycans in mucosal defense. However, the lack of significant effect of competitive inhibition by exogenous neoglycoproteins in this study emphasizes the complexity of Candida-epithelial cell adhesion events. |