| First Author | Nayeem N | Year | 2007 |
| Journal | Mol Cell Neurosci | Volume | 34 |
| Issue | 3 | Pages | 400-8 |
| PubMed ID | 17208451 | Mgi Jnum | J:123240 |
| Mgi Id | MGI:3717539 | Doi | 10.1016/j.mcn.2006.11.014 |
| Citation | Nayeem N, et al. (2007) Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella. Mol Cell Neurosci 34(3):400-8 |
| abstractText | Inherited mutations to the tumor suppressor PTEN sporadically lead to cerebellar gangliocytoma characterized by migration defects. This has been modeled by CNS-specific PTEN ablation in mice, but the underlying mechanism cannot be explained by the known role of PTEN in Akt/PKB inactivation. Here we show that the loss of PTEN in mouse cerebellar neurons causes neurodegeneration by hyperphosphorylation of tau and neurofilaments, and activation of Cdk5 and pERK1/2, suggesting that dysregulation of the PTEN/pAkt pathway can mediate neurodegeneration. |
