| First Author | Kang W | Year | 2008 |
| Journal | Biochem Biophys Res Commun | Volume | 376 |
| Issue | 3 | Pages | 573-7 |
| PubMed ID | 18804092 | Mgi Jnum | J:142716 |
| Mgi Id | MGI:3822055 | Doi | 10.1016/j.bbrc.2008.09.031 |
| Citation | Kang W, et al. (2008) Induction of follistatin precedes gastric transformation in gastrin deficient mice. Biochem Biophys Res Commun 376(3):573-7 |
| abstractText | We previously showed that antral gastric tumors develop in gastrin-deficient (Gas(-/-)) mice. Therefore Gas(-/-) mice were studied sequentially over 12 months to identify molecular mechanisms underlying gastric transformation. Fundic atrophy developed by 9 months in Gas(-/-) mice. Antral mucosal hyperplasia developed coincident with the focal loss of TFF1 and Muc5AC. Microarray analysis of 12 month Gas(-/-) tumors revealed an increase in follistatin, an activin/BMP antagonist. We found that elevated follistatin expression occurred in the proliferative neck zone of hyperplastic antrums, in antral tumors of Gas(-/-) mice, and also in human gastric cancers. Follistatin induced cyclin D1 and the trefoil factors TFF1 and TFF2 in a gastric cancer cell line. We concluded that antral hyperplasia in Gas(-/-) mice involves amplification of mucous cell lineages due to follistatin, suggesting its role in the development of antral gastric tumors. |
