| First Author | Kadereit S | Year | 2000 |
| Journal | J Immunol | Volume | 165 |
| Issue | 12 | Pages | 6896-901 |
| PubMed ID | 11120814 | Mgi Jnum | J:66112 |
| Mgi Id | MGI:1927993 | Doi | 10.4049/jimmunol.165.12.6896 |
| Citation | Kadereit S, et al. (2000) Negative regulation of CD8(+) T cell function by the IFN-induced and double-stranded RNA-activated kinase PKR. J Immunol 165(12):6896-901 |
| abstractText | The IFN-induced and dsRNA-activated kinase (PKR) mediates the antiviral and antiproliferative effects of IFN-alpha and IFN-gamma. Despite these findings, PKR:(-/-) mice have no overt immunological phenotype. Here we tested the role of PKR in cellular immunity by determining the induction and elicitation of contact hypersensitivity in PKR:(-/-) mice, a model of T cell-mediated immunity. When compared with wild type, the magnitude of contact hypersensitivity responses in PKR:(-/-) mice were 2-fold higher and of extended duration. This was also observed when naive recipients of immune CD8(+) T cells from sensitized PKR:(-/-) and CD4(+) T cells from sensitized wild-type PKR:(+/+) or PKR:(-/-) mice were challenged with hapten, indicating a regulatory defect intrinsic to the CD8(+) T cell population. Isolated lymph node T cells from PKR:(-/-) mice were hyperproliferative during Con A-mediated stimulation. These results implicate PKR for the first time in the growth control of mature T lymphocytes and give insight into the negative regulation of CD8(+) T cell-mediated immune responses. |
