| First Author | Soong L | Year | 1996 |
| Journal | Immunity | Volume | 4 |
| Issue | 3 | Pages | 263-73 |
| PubMed ID | 8624816 | Mgi Jnum | J:31943 |
| Mgi Id | MGI:79447 | Doi | 10.1016/s1074-7613(00)80434-3 |
| Citation | Soong L, et al. (1996) Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity 4(3):263-73 |
| abstractText | To study the role of CD40 ligand (CD40L) in the host immune responses against intracellular pathogens, we infected CD40L knockout (CD40L-/-) mice with Leishmania amazonensis. Although wild-type mice were susceptible to infection and developed progressive ulcerative lesions, tissue parasite burdens in CD40L-/- mice were significantly higher. This heightened susceptibility to infection was associated with an impaired T cell and macrophage activation and altered inflammatory response, as reflected by low levels of IFN gamma, lymphotoxin-tumor necrosis factor (LT-TNF), and nitric oxide (NO) production. Furthermore, CD40L-/- mice failed to generate a protective immune response after immunization. These results indicate an essential role of cognate CD40-CD40L interactions in the generation of cellular immune responses against an intracellular parasite. |
