| First Author | Carlring J | Year | 2011 |
| Journal | J Leukoc Biol | Volume | 89 |
| Issue | 5 | Pages | 697-706 |
| PubMed ID | 21330346 | Mgi Jnum | J:172096 |
| Mgi Id | MGI:5003417 | Doi | 10.1189/jlb.0310179 |
| Citation | Carlring J, et al. (2011) CD154-CD40 interactions in the control of murine B cell hematopoiesis. J Leukoc Biol 89(5):697-706 |
| abstractText | Interactions between CD40 and CD154 play a very important role in control of immune responses, including the delivery of T cell help to B cells and other APCs. Thus far, there has been no role postulated for CD40-CD154 interactions in hematopoiesis. We show here that CD40 is expressed on murine pro-B cells and that its ligation enhances pro-B cell proliferation in vitro and in vivo. In addition, CD154 mRNA is present in the BM. Moreover, we show that a deficiency in CD154 expression has effects on B cell hematopoiesis. Aged, CD154-deficient mice have significantly lower levels of B hematopoietic subsets downstream of pro-B cells in the BM. In addition, B lineage cells reconstitute more slowly following BMT into CD154-deficient recipients. We hypothesize that CD154 is expressed by radio-resistant cells in the BM and plays a role in fine-tuning B cell hematopoiesis. |
