| First Author | Grewal IS | Year | 1996 |
| Journal | Science | Volume | 273 |
| Issue | 5283 | Pages | 1864-7 |
| PubMed ID | 8791592 | Mgi Jnum | J:90888 |
| Mgi Id | MGI:3045441 | Doi | 10.1126/science.273.5283.1864 |
| Citation | Grewal IS, et al. (1996) Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science 273(5283):1864-7 |
| abstractText | The mechanism of CD40 ligand (CD40L)-mediated in vivo activation of CD4(+) T cells was examined by investigation of the development of experimental allergic encephalomyelitis (EAE) in CD40L-deficient mice that carried a transgenic T cell receptor specific for myelin basic protein. These mice failed to develop EAE after priming with antigen, and CD4(+) T cells remained quiescent and produced no interferon-gamma (IFN-gamma). T cells were primed to make IFN-gamma and induce EAE by providing these mice with B7.1(+) antigen-presenting cells (APCs). Thus, CD40L is required to induce costimulatory activity on APCs for in vivo activation of CD4(+) T cells to produce IFN-gamma and to evoke autoimmunity. |
