| First Author | Chervonsky AV | Year | 1995 |
| Journal | Immunity | Volume | 3 |
| Issue | 1 | Pages | 139-46 |
| PubMed ID | 7542547 | Mgi Jnum | J:27237 |
| Mgi Id | MGI:74654 | Doi | 10.1016/1074-7613(95)90166-3 |
| Citation | Chervonsky AV, et al. (1995) Direct physical interaction involving CD40 ligand on T cells and CD40 on B cells is required to propagate MMTV. Immunity 3(1):139-46 |
| abstractText | The propagation of mouse mammary tumor virus (MMTV) has been analyzed in mice defective for expression of CD40 ligand (CD40L). Mice with endogenous viral superantigen (SAG) delete T cells with cognate V beta independent of CD40L expression. Nevertheless, CD40L-mice do not show deletion of cognate T cells after being exposed to infectious MMTV and have greatly diminished viral replication. The response of CD40L- T cells to SAG in vitro is also impaired, but can be reconstituted by adding B cells activated by recombinant CD40L to express costimulatory molecules. Thus, direct CD40L-dependent B cell activation appears to be a critical step in the life cycle of MMTV. The initial step in SAG-dependent T cell activation, and hence the MMTV life cycle, may be mediated by non-B cells, because splenocytes from B cell-deficient SAG-transgenic mice are able to activate cognate T cells. |
