| First Author | Kiani A | Year | 1997 |
| Journal | Immunity | Volume | 7 |
| Issue | 6 | Pages | 849-60 |
| PubMed ID | 9430230 | Mgi Jnum | J:111250 |
| Mgi Id | MGI:3653521 | Doi | 10.1016/s1074-7613(00)80403-3 |
| Citation | Kiani A, et al. (1997) Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1. Immunity 7(6):849-60 |
| abstractText | Transcription factors of the NFAT family play a critical role in the immune response by activating the expression of cytokines and other inducible genes in antigen-stimulated cells. Here we show that a member of this family, NFAT1, is involved in down-regulating the late phase of IL-4 gene transcription, thus inhibiting T helper 2 responses. Whereas stimulated T cells from wild-type mice show a transient increase and then a rapid decline in the steady-state levels of IL-4 mRNA in vitro, the levels of IL-4 gene transcripts in NFAT1-deficient T cells are maintained at high levels under the same conditions. Consistent with this observation, NFAT1-/- mice are more susceptible to infection with Leishmania major. This report provides evidence that NFAT proteins regulate not only the initiation but also the termination of gene transcription. |
