| First Author | Meuwissen R | Year | 2001 |
| Journal | Oncogene | Volume | 20 |
| Issue | 45 | Pages | 6551-8 |
| PubMed ID | 11641780 | Mgi Jnum | J:72206 |
| Mgi Id | MGI:2151994 | Doi | 10.1038/sj.onc.1204837 |
| Citation | Meuwissen R, et al. (2001) Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene. Oncogene 20(45):6551-8 |
| abstractText | The onset of human lung cancer occurs through sequential mutations in oncogenes and tumor suppressor genes. Mutations in K-Ras play a prominent role in human non-small cell lung cancer. We have developed a mouse lung tumor model in which K-Ras can be sporadically activated through Cre-lox mediated somatic recombination. Adenoviral mediated delivery of Cre recombinase in lung epithelial cells gave rise to rapid onset of tumorigenesis, yielding pulmonary adenocarcinomas with 100% incidence after a short latency. The lung tumor lesions shared many features with human non-small cell lung cancer. Our data show that sporadic expression of the K-Ras oncogene is sufficient to elicit lung tumorigenesis. Therefore this model has many advantages over conventional transgenic models used thus far. |
