| First Author | Shintani N | Year | 2006 |
| Journal | Ann N Y Acad Sci | Volume | 1070 |
| Pages | 545-9 | PubMed ID | 16888223 |
| Mgi Jnum | J:341310 | Mgi Id | MGI:7466452 |
| Doi | 10.1196/annals.1317.079 | Citation | Shintani N, et al. (2006) Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyap1-/-). Ann N Y Acad Sci 1070:545-9 |
| abstractText | Genetic manipulation of pituitary adenylate cyclase-activating polypeptide (PACAP) in mice has uncovered its involvement in psychomotor function. We previously observed that mice lacking the Adcyap1 gene encoding the neuropeptide PACAP (Adcyap1-/-) displayed intense jumping behavior when placed in a novel environment such as an open field. Here, we show that Adcyap1-/- mice manifest jumping behavior as early as at least 6 weeks of age when compared with wild-type mice and that the selective serotonin (5-HT) reuptake inhibitor, fluoxetine, as well as the serotonin precursor, 5-hydroxytryptophan, suppress jumping behavior. Our previous study showed a slight decrease in 5-HT metabolite, 5-hydroxyindoleacetic acid (5-HIAA) in Adcyap1-/- mouse brain. Taken together, these results suggest that there is a developmental aspect to the jumping behavior seen in Adcyap1-/- mice, and that jumping behaviour may involve the serotonergic system. |
