| First Author | Takagi T | Year | 2001 |
| Journal | Nat Immunol | Volume | 2 |
| Issue | 11 | Pages | 1048-53 |
| PubMed ID | 11668343 | Mgi Jnum | J:72249 |
| Mgi Id | MGI:2152193 | Doi | 10.1038/ni728 |
| Citation | Takagi T, et al. (2001) Murine Schnurri-2 is required for positive selection of thymocytes. Nat Immunol 2(11):1048-53 |
| abstractText | A key step in T cell development involves the positive selection of cells that recognize antigen presented by self-major histocompatibility complex. Yet, the signals that are activated by T cell receptor engagement and lead to cell survival remain unclear. We show here that mice lacking the transcription factor Schnurri-2 (Shn-2), a large metal-finger protein, had severely defective positive selection of CD4+ and CD8+ cells. Drosophila Shn acts as a cofactor of Smad homolog and is required for Decapentaplegic signaling. Vertebrates have at least three Shn orthologs (Shn-1, Shn-2 and Shn-3), which are thought to act as nuclear targets in the bone morphogenetic protein-transforming growth factor-beta-activin signaling pathways. These data raised the possibility that the Smad-Shn-2 complex is involved in the thymic selection of T cells. |
