| First Author | Kimura MY | Year | 2005 |
| Journal | J Exp Med | Volume | 201 |
| Issue | 3 | Pages | 397-408 |
| PubMed ID | 15699073 | Mgi Jnum | J:96024 |
| Mgi Id | MGI:3528775 | Doi | 10.1084/jem.20040733 |
| Citation | Kimura MY, et al. (2005) Regulation of T helper type 2 cell differentiation by murine Schnurri-2. J Exp Med 201(3):397-408 |
| abstractText | Schnurri (Shn) is a large zinc finger protein implicated in cell growth, signal transduction, and lymphocyte development. Vertebrates possess at least three Shn orthologues (Shn-1, Shn-2, and Shn-3), which appear to act within the bone morphogenetic protein, transforming growth factor beta, and activin signaling pathways. However, the physiological functions of the Shn proteins remain largely unknown. In Shn-2-deficient mice, mature peripheral T cells exhibited normal anti-T cell receptor-induced proliferation, although there was dramatic enhancement in the differentiation into T helper type (Th)2 cells and a marginal effect on Th1 cell differentiation. Shn-2-deficient developing Th2 cells showed constitutive activation of nuclear factor kappaB (NF-kappaB) and enhanced GATA3 induction. Shn-2 was able to compete with p50 NF-kappaB for binding to a consensus NF-kappaB motif and inhibit NF-kappaB-driven promoter activity. Thus, Shn-2 plays a crucial role in the control of Th2 cell differentiation by regulating NF-kappaB function. |
