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Publication : Subcellular specificity of cannabinoid effects in striatonigral circuits.

First Author  Soria-Gomez E Year  2021
Journal  Neuron Volume  109
Issue  9 Pages  1513-1526.e11
PubMed ID  33770505 Mgi Jnum  J:306938
Mgi Id  MGI:6706887 Doi  10.1016/j.neuron.2021.03.007
Citation  Soria-Gomez E, et al. (2021) Subcellular specificity of cannabinoid effects in striatonigral circuits. Neuron 109(9):1513-1526.e11
abstractText  Recent advances in neuroscience have positioned brain circuits as key units in controlling behavior, implying that their positive or negative modulation necessarily leads to specific behavioral outcomes. However, emerging evidence suggests that the activation or inhibition of specific brain circuits can actually produce multimodal behavioral outcomes. This study shows that activation of a receptor at different subcellular locations in the same neuronal circuit can determine distinct behaviors. Pharmacological activation of type 1 cannabinoid (CB1) receptors in the striatonigral circuit elicits both antinociception and catalepsy in mice. The decrease in nociception depends on the activation of plasma membrane-residing CB1 receptors (pmCB1), leading to the inhibition of cytosolic PKA activity and substance P release. By contrast, mitochondrial-associated CB1 receptors (mtCB1) located at the same terminals mediate cannabinoid-induced catalepsy through the decrease in intra-mitochondrial PKA-dependent cellular respiration and synaptic transmission. Thus, subcellular-specific CB1 receptor signaling within striatonigral circuits determines multimodal control of behavior.
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