| Primary Identifier | MGI:2182936 | Allele Type | Targeted |
| Gene | Slc18a2 | Transmission | Germline |
| Strain of Origin | 129P2/OlaHsd | Is Recombinase | false |
| Is Wild Type | false |
| description | ES cell line = CGR8.8 (subline of CGR8). Phenotypic Similarity to Human Syndrome: Parkinson Disease (J:70606, J:150414, J:214496). |
| molecularNote | As a result of incorrect gene targeting, a neomycin resistance cassette inserted between exons 2 and 3 via homologous recombination. A decrease in gene expression in homozygous mutants was observed by RT-PCR analysis of total midbrain RNA using primers to exons 2 and 12. Western blot analysis of striatal membrane extracts from homozygous mutants showed greater than 95% decrease in protein expression compared to wild-type. |
