| First Author | Ohinata K | Year | 2004 |
| Journal | Peptides | Volume | 25 |
| Issue | 12 | Pages | 2135-8 |
| PubMed ID | 15572202 | Mgi Jnum | J:102523 |
| Mgi Id | MGI:3607692 | Doi | 10.1016/j.peptides.2004.07.009 |
| Citation | Ohinata K, et al. (2004) The anorectic effect of neurotensin is mediated via a histamine H1 receptor in mice. Peptides 25(12):2135-8 |
| abstractText | Neurotensin (NT), a tridecapeptide found in the mammalian brain and peripheral tissues, induces a decrease in food intake after central administration. In this investigation, we examine whether the histaminergic system is involved in NT-induced suppression of feeding. Intracerebroventricular injection of NT (0.1-1 nmol/mouse) led to dose-dependent inhibition of food intake in fasted ddY mice. The anorectic effect induced by NT (0.1 nmol/mouse) was ameliorated upon co-administration of pyrilamine (3 nmol/mouse), an antagonist for histomine H1 receptor. The NT-induced anorectic effect was partially ameliorated in H1 knockout mice. The findings suggest that the H1 receptor in part mediates the NT-induced suppression of food intake. |
