| First Author | Fienberg AA | Year | 1998 |
| Journal | Science | Volume | 281 |
| Issue | 5378 | Pages | 838-42 |
| PubMed ID | 9694658 | Mgi Jnum | J:78045 |
| Mgi Id | MGI:2183164 | Doi | 10.1126/science.281.5378.838 |
| Citation | Fienberg AA, et al. (1998) DARPP-32: regulator of the efficacy of dopaminergic neurotransmission. Science 281(5378):838-42 |
| abstractText | Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein (32 kilodaltons) (DARPP-32), which is enriched in all neurons that receive a dopaminergic input, is converted in response to dopamine into a potent protein phosphatase inhibitor. Mice generated to contain a targeted disruption of the DARPP-32 gene showed profound deficits in their molecular, electrophysiological, and behavioral responses to dopamine, drugs of abuse, and antipsychotic medication. The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission. |
