| First Author | Hiroi N | Year | 1999 |
| Journal | Eur J Neurosci | Volume | 11 |
| Issue | 3 | Pages | 1114-8 |
| PubMed ID | 10103106 | Mgi Jnum | J:54156 |
| Mgi Id | MGI:1334154 | Doi | 10.1046/j.1460-9568.1999.00570.x |
| Citation | Hiroi N, et al. (1999) Neuronal and behavioural abnormalities in striatal function in DARPP-32-mutant mice. Eur J Neurosci 11(3):1114-8 |
| abstractText | We investigated the role of the protein phosphatase inhibitor, dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32), in the expression of striatal neuropeptides and in biochemical and behavioural responses to repeated cocaine administration, using DARPP-32 knock- out mice. The striatum of DARPP-32-mutant mice showed heightened substance-P-like immunoreactivity, but normal levels of other neuropeptides. Repeated cocaine administration increased levels of Delta FosB, a Fos family transcription factor in the striatum of wild-type mice, and this increase was abolished in DARPP-32-mutant mice. Cocaine (20 mg/kg) acutely induced the same level of locomotor activity in the mutant and wild-type mice, but the mutants showed a higher rate of locomotor sensitization to repeated cocaine exposures. These data show that DARPP-32 is involved in regulating substance P expression in the striatonigral pathway, and in biochemical and behavioural plasticity with chronic administration of cocaine. |
