| First Author | Calabresi P | Year | 2000 |
| Journal | J Neurosci | Volume | 20 |
| Issue | 22 | Pages | 8443-51 |
| PubMed ID | 11069952 | Mgi Jnum | J:120025 |
| Mgi Id | MGI:3703691 | Doi | 10.1523/JNEUROSCI.20-22-08443.2000 |
| Citation | Calabresi P, et al. (2000) Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity. J Neurosci 20(22):8443-51 |
| abstractText | A complex chain of intracellular signaling events, critically important in motor control, is activated by the stimulation of D1-like dopamine (DA) receptors in striatal neurons. At corticostriatal synapses on medium spiny neurons, we provide evidence that the D1-like receptor-dependent activation of DA and cyclic adenosine 3',5' monophosphate-regulated phosphoprotein 32 kDa is a crucial step for the induction of both long-term depression (LTD) and long-term potentiation (LTP), two opposing forms of synaptic plasticity. In addition, formation of LTD and LTP requires the activation of protein kinase G and protein kinase A, respectively, in striatal projection neurons. These kinases appear to be stimulated by the activation of D1-like receptors in distinct neuronal populations. |
