| First Author | Sachs HH | Year | 2007 |
| Journal | Neuroreport | Volume | 18 |
| Issue | 16 | Pages | 1729-33 |
| PubMed ID | 17921877 | Mgi Jnum | J:127125 |
| Mgi Id | MGI:3763005 | Doi | 10.1097/WNR.0b013e3282f0d3f4 |
| Citation | Sachs HH, et al. (2007) Galanin plays a role in the conditioning lesion effect in sensory neurons. Neuroreport 18(16):1729-33 |
| abstractText | Sensory neurons show enhanced neurite outgrowth in vivo and in vitro following a conditioning lesion. Previous studies have shown that these effects are dependent on two members of the gp130 family of cytokines, leukemia inhibitory factor and interleukin-6. Here, we asked whether galanin, a neuropeptide induced by these cytokines, plays a role in the conditioning lesion response. Following a conditioning lesion, neurite outgrowth in culture was reduced in sensory neurons from galanin -/- mice compared with those from wild type controls. In neurons from wild type mice, the length of the longest neurite was increased 2.4-fold after a conditioning lesion, compared with 1.8-fold in neurons from knockout animals. The results indicate that the induction of galanin plays an important role in triggering the conditioning lesion response. |
