| First Author | Bergsbaken T | Year | 2015 |
| Journal | Nat Immunol | Volume | 16 |
| Issue | 4 | Pages | 406-14 |
| PubMed ID | 25706747 | Mgi Jnum | J:231497 |
| Mgi Id | MGI:5771638 | Doi | 10.1038/ni.3108 |
| Citation | Bergsbaken T, et al. (2015) Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8(+) T cells responding to infection. Nat Immunol 16(4):406-14 |
| abstractText | We report that oral infection with Yersinia pseudotuberculosis results in the development of two distinct populations of pathogen-specific CD8(+) tissue-resident memory T cells (TRM cells) in the lamina propria. CD103(-) T cells did not require transforming growth factor-beta (TGF-beta) signaling but were true resident memory cells. Unlike CD103(+)CD8(+) T cells, which were TGF-beta dependent and were scattered in the tissue, CD103(-)CD8(+) T cells clustered with CD4(+) T cells and CX3CR1(+) macrophages and/or dendritic cells around areas of bacterial infection. CXCR3-dependent recruitment of cells to inflamed areas was critical for development of the CD103(-) population and pathogen clearance. Our studies have identified the 'preferential' development of CD103(-) TRM cells in inflammatory microenvironments within the lamina propria and suggest that this subset has a critical role in controlling infection. |
