| First Author | Zhu L | Year | 2013 |
| Journal | Endocrinology | Volume | 154 |
| Issue | 1 | Pages | 150-8 |
| PubMed ID | 23211707 | Mgi Jnum | J:194628 |
| Mgi Id | MGI:5474423 | Doi | 10.1210/en.2012-2007 |
| Citation | Zhu L, et al. (2013) Steroid receptor coactivator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology 154(1):150-8 |
| abstractText | Estrogen receptor-alpha (ERalpha) expressed by hypothalamic proopiomelanocortin and steroidogenic factor-1 neurons largely mediates the antiobesity effects of estrogens in females. However, the critical molecular events that are coupled to ERalpha and mediate estrogenic effects on energy balance remain unknown. In the current study, we demonstrated that steroid receptor coactivator-1 (SRC1), a nuclear receptor coactivator, is abundantly expressed by both proopiomelanocortin and steroidogenic factor-1 neurons. We further showed that central administration of an ERalpha agonist, propyl pyrazole triol, acutely increases physical interaction between SRC1 and ERalpha in the hypothalamus. Finally, we demonstrated that the effects of estrogens on energy homeostasis are significantly blunted in female mice lacking SRC1 globally. Collectively our results indicate that SRC1 is functionally required to mediate the antiobesity effects of estrogen-ERalpha signals. |
