| First Author | Jokic N | Year | 2006 |
| Journal | EMBO Rep | Volume | 7 |
| Issue | 11 | Pages | 1162-7 |
| PubMed ID | 17039253 | Mgi Jnum | J:116078 |
| Mgi Id | MGI:3692826 | Doi | 10.1038/sj.embor.7400826 |
| Citation | Jokic N, et al. (2006) The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model. EMBO Rep 7(11):1162-7 |
| abstractText | Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron loss and muscle wasting. In muscles of ALS patients, Nogo-A-a protein known to inhibit axon regeneration-is ectopically expressed at levels that correlate with the severity of the clinical symptoms. We now show that the genetic ablation of Nogo-A extends survival and reduces muscle denervation in a mouse model of ALS. In turn, overexpression of Nogo-A in wild-type muscle fibres leads to shrinkage of the postsynapse and retraction of the presynaptic motor ending. This suggests that the expression of Nogo-A occurring early in ALS skeletal muscle could cause repulsion and destabilization of the motor nerve terminals, and subsequent dying back of the axons and motor neurons. |
