| First Author | Nabben M | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 24 | Pages | 4010-7 |
| PubMed ID | 22115550 | Mgi Jnum | J:180441 |
| Mgi Id | MGI:5306275 | Doi | 10.1016/j.febslet.2011.11.012 |
| Citation | Nabben M, et al. (2011) Significance of uncoupling protein 3 in mitochondrial function upon mid- and long-term dietary high-fat exposure. FEBS Lett 585(24):4010-7 |
| abstractText | Uncoupling protein 3 (UCP3) may reduce mitochondrial ROS production, and thereby protect against mitochondrial dysfunction in skeletal muscle. UCP3 has been suggested to specifically fulfill this role under high-fat conditions. Here we show that UCP3 knockout mice indeed have elevated mitochondrial ROS production after short-term (8 weeks) high-fat feeding. After 26 weeks of high-fat feeding, UCP3 knockout mice exhibited reduced mitochondrial function as measured ex vivo in isolated mitochondria. In conclusion, these data suggest that UCP3 may have a role in the protection of mitochondria against lipid-induced mitochondrial dysfunction, but only after long-term exposure to high-fat. |
