| First Author | Hoeks J | Year | 2006 |
| Journal | FEBS Lett | Volume | 580 |
| Issue | 5 | Pages | 1371-5 |
| PubMed ID | 16455084 | Mgi Jnum | J:106901 |
| Mgi Id | MGI:3619754 | Doi | 10.1016/j.febslet.2006.01.059 |
| Citation | Hoeks J, et al. (2006) The effect of high-fat feeding on intramuscular lipid and lipid peroxidation levels in UCP3-ablated mice. FEBS Lett 580(5):1371-5 |
| abstractText | Uncoupling protein-3 (UCP3) has been suggested to protect against lipid-induced oxidative damage. Therefore, we studied intramuscular lipid peroxide levels and high-fat diet induced alterations in muscle lipid metabolism of UCP3-ablated mice. UCP3-/- mice showed approximately 3-fold higher levels of intramuscular lipid peroxides upon standard chow feeding, compared to wild-type littermates. Remarkably, this difference was no longer apparent on the high-fat diet. However, upon high-fat feeding, intramuscular triacylglycerol levels were approximately 50% lower in UCP3-/- mice, in comparison to UCP3+/+ animals. Succinate dehydrogenase activity, and total protein content of the muscle fatty acid transporter FAT/CD36 were however similar between UCP3-/- and UCP3+/+ mice. |
