| First Author | Zheng Y | Year | 2012 |
| Journal | J Exp Med | Volume | 209 |
| Issue | 12 | Pages | 2157-63 |
| PubMed ID | 23129747 | Mgi Jnum | J:190973 |
| Mgi Id | MGI:5451112 | Doi | 10.1084/jem.20120342 |
| Citation | Zheng Y, et al. (2012) Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo. J Exp Med 209(12):2157-63 |
| abstractText | T cell receptor engagement in the absence of costimulation results in a hyporesponsive state termed anergy. Understanding the transcriptional regulation of other T cell differentiation states has provided critical information regarding the biology of T cell regulation in vivo. However, the transcriptional regulation of T cell anergy has been poorly understood. Using the key anergy target gene diacylglycerol kinase (DGK) alpha as a focal point, we identified early growth response gene 2 (Egr2) as a central transcription factor that regulates the anergic state. Conditional Egr2 deletion in peripheral T cells abolishes induced expression of DGK-alpha and other anergy genes and restores Ras/MAPK signaling, IL-2 production, and proliferation upon attempted anergy induction. Using superantigen- and tumor-induced anergy models, we found that Egr2 is necessary for anergy induction in vivo. Collectively, our results implicate Egr2 as an essential transcriptional regulator of the T cell anergy program. |
