| Primary Identifier | MGI:2183769 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(PMP22)C1Clh |
| Strain of Origin | (C57BL/6J x CBA/Ca)F1 | Is Recombinase | false |
| Is Wild Type | false |
| description | Heterozygous animals show no phenotype but homozygous transgenic animals exhibit weakness and progressive paralysis of the hind limbs. |
| molecularNote | A YAC containing the human PMP22 gene with 300 kb of upstream and 100 kb of downstream sequences was used as the transgene. STS analysis using 6 markers spanning the YAC showed the integrated transgene was intact (including the region containing PMP22) except for the marker representing the right arm of the YAC. Founder C1 carries 2 copies of the human transgene on chromosome 7 with an expression level half that of the endogenous mouse gene. |
