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Allele : Tg(PMP22)C22Clh transgene insertion C22, Clare Huxley
Primary Identifier  MGI:2183770 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(PMP22)C22Clh
Inheritance Mode  Dominant Strain of Origin  (C57BL/6J x CBA/Ca)F1
Is Recombinase  false Is Wild Type  false
molecularNote  A YAC containing the human PMP22 gene with 300 kb of upstream and 100 kb of downstream sequences was used as the transgene. STS analysis using 6 markers spanning the YAC showed the integrated transgene was largely intact including the region containing PMP22. Founder C22 carries 8 copies of the human transgene on chromosome 8 with an expression pattern similar to that of the endogenous mouse gene. The expression level of each human transgene is approximately 0.4X that of one mouse gene.
  • mutations:
  • Insertion
  • synonyms:
  • C22,
  • C22
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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20 Publication categories

Trail: Allele




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