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Allele : Tg(Pmp22)My41Clh transgene insertion My41, Clare Huxley

Primary Identifier  MGI:2183742 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(Pmp22)My41Clh
Strain of Origin  (C57BL/6J x CBA/Ca)F2 Is Recombinase  false
Is Wild Type  false
description  Transgenic offspring of founder My41 developed unstable gait and progressive hind limb weakness by 3 weeks of age. Most animals were sacrificed at 5 months.
molecularNote  A 310 kb YAC containing the entire mouse Pmp22 gene and at least 60 kb and 90 kb of upstream and downstream sequences, respectively, was used as the transgene. Three lines were created (Jdelta42, My39 and My41) with My41 selected as the representative line as it is the only one with myelination defects.
  • mutations:
  • Insertion
  • synonyms:
  • My41,
  • My41
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

3 Publication categories

Trail: Allele