| First Author | Packiriswamy N | Year | 2012 |
| Journal | Cell Immunol | Volume | 272 |
| Issue | 2 | Pages | 107-11 |
| PubMed ID | 22078319 | Mgi Jnum | J:181375 |
| Mgi Id | MGI:5311099 | Doi | 10.1016/j.cellimm.2011.10.019 |
| Citation | Packiriswamy N, et al. (2012) Overlapping and distinct roles of GRK5 in TLR2-, and TLR3-induced inflammatory response in vivo. Cell Immunol 272(2):107-11 |
| abstractText | G-protein coupled receptor kinase-5 (GRK5) is a recently described NFkappaB regulator in TLR4 signaling pathway. To determine whether the role of GRK5 is MyD88- or TRIF-dependent, we injected wild type and GRK5 knockout mice with Pam3CSK4 (MyD88-dependent TLR1/2 ligand) and Poly(I:C) (TRIF-dependent TLR3 ligand) and examined the in vivo systemic inflammatory response. Our results demonstrate that GRK5 regulates IL-12p40 and G-CSF via a mechanism that is common to both MyD88 and TRIF. However, GRK5 regulates IL-5 and MCP-1 in a MyD88-dependent but TNFalpha in a TRIF-dependent manner. Together, our results demonstrate multiple roles of GRK5 in TLR signaling. |
