| Primary Identifier | MGI:2183390 | Allele Type | Targeted |
| Attribute String | Not Specified | Gene | Gata2 |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A valine to glycine substitute at amino acid 296 (V296G) of exon 4, a floxed neo cassette insertion in the downstream intron, and a loxP site upstream of exon 4, were introduced to the gene via homologous recombination. The V296G mutation disrupts the FOG-binding region without affecting DNA-binding ability. The neo cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. |
