| First Author | Huang H | Year | 2018 |
| Journal | Clin Exp Immunol | Volume | 194 |
| Issue | 1 | Pages | 17-26 |
| PubMed ID | 30260469 | Mgi Jnum | J:321153 |
| Mgi Id | MGI:6883502 | Doi | 10.1111/cei.13164 |
| Citation | Huang H, et al. (2018) Vitamin D receptor interacts with NLRP3 to restrict the allergic response. Clin Exp Immunol 194(1):17-26 |
| abstractText | Vitamin D receptor (VDR) mediates various biochemical activities between the cytoplasm and the nucleus in the cell. The nucleotide-binding, oligomerization domain (NOD)-like receptor family, pyrin domain containing 3 (NLRP3) protein is involved in the T helper type 2 (Th2) response. This study tests a hypothesis that VDR interacts with NLRP3 to restrict the Th2-biased response. In this study, VDR(-/-) mice and WT (WT) mice were used. Th2 cell differentiation between VDR(-/-) mice and WT mice was observed. We observed that CD4(+) T cell activation was higher in VDR(-/-) mice. The VDR(-/-)CD4(+) T cells were prone to Th2 polarization. VDR(-/-) mice produced more immunoglobulin (Ig)E. VDR bound NLRP3 to prevent Th2 differentiation by restricting IL4 gene transcription. Th2 biased inflammation spontaneously developed in the intestine of VDR(-/-) mice. In conclusion, VDR binds NLRP3 to restrict IL4 gene transcription and prevent biased Th2 polarization. |
