| First Author | Miyoshi G | Year | 2007 |
| Journal | J Neurosci | Volume | 27 |
| Issue | 29 | Pages | 7786-98 |
| PubMed ID | 17634372 | Mgi Jnum | J:123317 |
| Mgi Id | MGI:3717981 | Doi | 10.1523/JNEUROSCI.1807-07.2007 |
| Citation | Miyoshi G, et al. (2007) Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors. J Neurosci 27(29):7786-98 |
| abstractText | Inhibitory GABAergic interneurons of the mouse neocortex are a highly heterogeneous population of neurons that originate from the ventral telencephalon and migrate tangentially up into the developing cortical plate. The majority of cortical interneurons arise from a transient embryonic structure known as the medial ganglionic eminence (MGE), but how the remarkable diversity is specified in this region is not known. We have taken a genetic fate mapping strategy to elucidate the temporal origins of cortical interneuron subtypes within the MGE. We used an inducible form of Cre under the regulation of Olig2, a basic helix-loop-helix transcription factor highly expressed in neural progenitors of the MGE. We observe that the physiological subtypes of cortical interneurons are, to a large degree, unique to their time point of generation. |
