| Primary Identifier | MGI:2183413 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Hypomorph | Gene | Lig1 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd-Hprt1<b-m3> |
| Is Recombinase | false | Is Wild Type | false |
| description | Mice were generated from mutant HM-1 ES cells heterozygous for Lig1tm2Dwm. |
| molecularNote | A C to T transversion in codon 771 (exon 23) resulted in the substitution of Arg with Trp (R771W), a mutation initially identified in a patient with symptoms similar to Bloom's syndrome. Sequence analysis of RT-PCR products confirmed that the point mutation in exon 23 was the only change in the coding region of the endogenous gene. |
