| First Author | Oyamada Y | Year | 2005 |
| Journal | Respir Physiol Neurobiol | Volume | 145 |
| Issue | 2-3 | Pages | 143-51 |
| PubMed ID | 15705530 | Mgi Jnum | J:101862 |
| Mgi Id | MGI:3605588 | Doi | 10.1016/j.resp.2004.11.003 |
| Citation | Oyamada Y, et al. (2005) Role of Kir2.2 in hypercapnic ventilatory response during postnatal development of mouse. Respir Physiol Neurobiol 145(2-3):143-51 |
| abstractText | In order to determine the role of Kir2.2 in the hypercapnic ventilatory response (HCVR) during postnatal development, we measured the response of the Kir2.2-knockout (Kir2.2-/-) mouse in an unanesthetized unrestrained state by means of pressure plethysmography on postnatal days 9-10, 14-15 and 18, and compared the response with that in its wild counterpart, the FVB mouse. We also examined developmental changes in m-RNA expression of Kir2.2 in the brainstem of the FVB mouse using quantitative real-time PCR assay. Kir2.2-/- exhibited a smaller increase in tidal volume and minute ventilation volume than the FVB mouse in response to hypercapnic challenge on days 14-15. Meanwhile, the FVB mouse showed a transient increase in m-RNA expression of Kir2.2 in the brainstem on days 14-15. These findings suggest that Kir2.2 in the brainstem plays a transient role in HCVR, possibly through central ventilatory chemosensitivity, during postnatal development. |
