| First Author | Redmann SM Jr | Year | 2006 |
| Journal | Biochem Biophys Res Commun | Volume | 351 |
| Issue | 4 | Pages | 860-4 |
| PubMed ID | 17097059 | Mgi Jnum | J:116654 |
| Mgi Id | MGI:3694621 | Doi | 10.1016/j.bbrc.2006.10.129 |
| Citation | Redmann SM Jr, et al. (2006) AgRP-deficiency could lead to increased lifespan. Biochem Biophys Res Commun 351(4):860-4 |
| abstractText | The Agouti-related protein (AgRP) is a central orexigenic peptide leading to increased food intake when ubiquitously overexpressed. AgRP-deficient (AgRP(-/-)) mice have either no phenotype or present an age-related leanness. In this study, AgRP(-/-) mice were fed alternate high fat or low fat diets in an effort to determine whether AgRP is a mediating factor for the effects of dietary fat on metabolic parameters. There were no striking metabolic differences between AgRP(-/-) and the equally obese wild type littermates but AgRP(-/-) mice displayed a significantly longer lifespan. The point estimate of median survival for the AgRP(-/-) group was 9.8% greater while the significantly low hazard ratio (0.494) suggests that mortality incidence of AgRP(-/-) mice is less than one-half that of the wild type reference population. It is concluded that although AgRP(-/-) mice become morbidly obese consuming a high fat diet (a landmark feature for a shortened lifespan), they seem to overcome obesity- and age-related pathologies and live significantly longer than their metabolically similar wild type littermates. |
