| First Author | Chen AS | Year | 2000 |
| Journal | Transgenic Res | Volume | 9 |
| Issue | 2 | Pages | 145-54 |
| PubMed ID | 10951699 | Mgi Jnum | J:63775 |
| Mgi Id | MGI:1861563 | Doi | 10.1023/a:1008983615045 |
| Citation | Chen AS, et al. (2000) Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Res 9(2):145-54 |
| abstractText | We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic rate in wildtype mice, while MC-4R knockout mice are insensitive to the effects of MT-II on metabolic rate. MC-4R knockout mice are also insensitive to the effects of MT-II on reducing food intake. We conclude that MC-4R can mediate control of both metabolic rate and food intake in mice. We infer that a role for MC-3R in mediating the acute effects of MT-II on basal metabolic rate and food intake in wildtype mice seems limited. |
