| First Author | Groeneveld GJ | Year | 2004 |
| Journal | Brain Res | Volume | 1021 |
| Issue | 1 | Pages | 128-31 |
| PubMed ID | 15328040 | Mgi Jnum | J:91976 |
| Mgi Id | MGI:3051425 | Doi | 10.1016/j.brainres.2004.06.024 |
| Citation | Groeneveld GJ, et al. (2004) Ovariectomy and 17beta-estradiol modulate disease progression of a mouse model of ALS. Brain Res 1021(1):128-31 |
| abstractText | The incidence of amyotrophic lateral sclerosis (ALS) is higher among men than women but rises in women after the menopause. Estrogens may play a protective role. Treatment with estrogens has been shown to be neuroprotective in models of several neurodegenerative diseases. We therefore determined the effect of ovariectomy on female G93A mSOD1 transgenic mice, and the effect of subsequent treatment with 17beta-estradiol (E2). Ovariectomy led to a significant acceleration of disease progression of the mice, and high-dose E2 treatment significantly delayed disease progression of ovariectomized G93A mSOD1 transgenic mice. We conclude that treatment with E2 may also delay disease progression of post-menopausal women with ALS. |
