| First Author | Lepore AC | Year | 2007 |
| Journal | Brain Res | Volume | 1185 |
| Pages | 256-65 | PubMed ID | 17963733 |
| Mgi Jnum | J:128943 | Mgi Id | MGI:3768310 |
| Doi | 10.1016/j.brainres.2007.09.034 | Citation | Lepore AC, et al. (2007) Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1(G93A) model of ALS. Brain Res 1185:256-65 |
| abstractText | The potent neuroprotective activities of neurotrophic factors, including insulin-like growth factor 1 (IGF-1), make them promising candidates for treatment of amyotrophic lateral sclerosis (ALS). In an effort to maximize rate of motor neuron transduction, achieve high levels of spinal IGF-1 and thus enhance therapeutic benefit, we injected an adeno-associated virus 2 (AAV2)-based vector encoding human IGF-1 (CERE-130) into lumbar spinal cord parenchyma of SOD1(G93A) mice. We observed robust and long-term intraspinal IGF-1 expression and partial rescue of lumbar spinal cord motor neurons, as well as sex-specific delayed disease onset, weight loss, decline in hindlimb grip strength and increased animal survival. |
