| First Author | Nawa M | Year | 2012 |
| Journal | Cell Death Differ | Volume | 19 |
| Issue | 8 | Pages | 1398-407 |
| PubMed ID | 22388351 | Mgi Jnum | J:204628 |
| Mgi Id | MGI:5532900 | Doi | 10.1038/cdd.2012.19 |
| Citation | Nawa M, et al. (2012) Reduced expression of BTBD10, an Akt activator, leads to motor neuron death. Cell Death Differ 19(8):1398-407 |
| abstractText | BTBD10, an Akt interactor, activates Akt by decreasing the protein phosphatase 2A-mediated dephosphorylation and inactivation of Akt. Overexpression of BTBD10 suppresses motor neuron death that is induced by a familial amyotrophic lateral sclerosis (ALS)-linked superoxide dismutase 1 (SOD1) mutant, G93A-SOD1 in vitro. In this study, we further investigated the BTBD10-mediated suppression of motor neuron death. We found that the small interfering RNA-mediated inhibition of BTBD10 expression led to the death of cultured motor neurons. In Caenorhabditis elegans (C. elegans), disruption of the btbd-10 gene caused not only loss of neurons, including both motor and touch-receptor neurons, but also a locomotion defect. In addition, we found that the expression of BTBD10 was generally decreased in the motor neurons from patients of sporadic ALS and transgenic mice overexpressing G93A-SOD1 (G93A-SOD1-transgenic mice). Collectively, these results suggest that the reduced expression of BTBD10 leads to motor neuron death both in vitro and in vivo. |
