| First Author | Riddoch-Contreras J | Year | 2009 |
| Journal | Exp Neurol | Volume | 215 |
| Issue | 2 | Pages | 281-9 |
| PubMed ID | 19038252 | Mgi Jnum | J:144380 |
| Mgi Id | MGI:3830804 | Doi | 10.1016/j.expneurol.2008.10.014 |
| Citation | Riddoch-Contreras J, et al. (2009) Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1(G93A) mice. Exp Neurol 215(2):281-9 |
| abstractText | Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by motoneuron degeneration. Although viral delivery of IGF-I has shown therapeutic efficacy in the SOD1(G93A) mouse model of ALS, clinical trials of IGF-I in ALS patients have led to conflicting results. Here we examine the effects of an IGF-I splice variant, mechano-growth factor (MGF) which has previously been shown to have greater neuroprotective effects than IGF-I in a number of models of neurodegeneration. A mammalian expression plasmid containing either MGF or, for comparison, the IGF-I cDNA sequence was delivered to the hindlimb muscles of SOD1(G93A) mice at 70 days of age, at symptom onset. Treatment with either IGF-I or MGF resulted in a significant improvement in hindlimb muscle strength, and an increase in motor unit and motoneuron survival. Significantly more motoneurons survived in MGF treated mice. |
