| First Author | Guerra C | Year | 2001 |
| Journal | J Clin Invest | Volume | 108 |
| Issue | 8 | Pages | 1205-13 |
| PubMed ID | 11602628 | Mgi Jnum | J:72231 |
| Mgi Id | MGI:2152020 | Doi | 10.1172/JCI13103 |
| Citation | Guerra C, et al. (2001) Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance. J Clin Invest 108(8):1205-13 |
| abstractText | Although insulin regulates metabolism in both brown and white adipocytes, the role of these tissues in energy storage and utilization is quite different. Recombination technology using the Cre-loxP approach allows inactivation of the insulin receptor in a tissue-specific manner. Mice lacking insulin receptors in brown adipocytes show an age-dependent loss of interscapular brown fat but increased expression of uncoupling protein-1 and -2. In parallel, these mice develop an insulin-secretion defect resulting in a progressive glucose intolerance, without insulin resistance. This model provides direct evidence for not only a role for the insulin receptors in brown fat adipogenesis, the data also suggest a novel role of brown adipose tissue in the regulation of insulin secretion and glucose homeostasis. |
